What exactly are nanoparticles? What is meant by “exposure”? When do toxicologists speak of a risk? This and many more questions regarding research on safety aspects of nanomaterials are answered here: www.nanoobjects.info
In recent years, researchers have realized that many products, including pharmaceuticals, have ended up where they are not supposed to be — in our drinking water. But now scientists from the Leuphana University Luneburg / Germany have developed a way to make drugs that break down into harmless compounds before they contaminate our taps as part of the BMBF-funded project NanoPHARM. Their open access report appears in ACS' journal Environmental Science & Technology.
A wide range of active ingredients originating from pesticides, shampoos, lotions, cosmetics, disinfectants and drugs get washed into sewage systems or rivers and streams, ending up in our tap water. Scientists don't have a complete picture yet of what effects these substances have on wildlife and human health, but they are a major concern. Researchers have detected them in low levels in streams and rivers across the United States and in other countries. To address the specific problem of medications in the environment, Klaus Kümmerer and colleagues made tweaks to pharmaceuticals so they degrade after they've passed through both the body and sewage treatment systems, which aren't capable of scrubbing wastewater of all contaminants.
The researchers chose to work with a commonly used drug called propranolol — a beta blocker prescribed to treat high blood pressure and to prevent heart problems. It is very stable and has been found in sewage. They made a small molecular change in its structure that didn't affect its beta blocking activity but allowed it to break down more easily than the original form. Further studies are needed, but initial testing showed that the altered drug and its by-products are likely not toxic. The researchers suggest that a similar approach could be used to re-design other classes of drugs and chemicals to make them more environmentally friendly, too.
Original Publication (Open Access)
Rastogi T., Leder C., Kummerer K. (2015). Re-Designing of Existing Pharmaceuticals for Environmental Biodegradability: A Tiered Approach with beta-Blocker Propranolol as an Example. Environ Sci Technol. DOI: 10.1021/acs.est.5b03051
Information on the sponsorship programmes of the German Federal Ministry of Education and Research on nanotechnologies for humans and the environment.
A database with important and generally understandable aspects on health and environment of applied nanomaterials as well as facts on the safety of manufactured nanomaterials.
The chapters on release, exposure, uptake and behavior of nanomaterials in the human body and in the environment as well as the risk assessment will give you a first overview.
Thu Dec 05 @ 9:00AM - 03:00PM Advanced Materials - 1st Thematic Conference |
Mon Nov 16 @ 8:00AM - 05:00PM Nanosafe 2020 |